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Simkania negevensis and acute cellular rejection in lung transplant recipients
Author(s) -
Jamal Alainna J.,
Resende Mariangela R.,
Prochnow Taisa,
McGilvray Ian,
Pilewski Joseph M.,
Crespo Maria M.,
Singer Lianne G.,
McCurry Kenneth R.,
Kolls Jay K.,
Keshavjee Shaf,
Liles W. Conrad,
Husain Shahid
Publication year - 2015
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12571
Subject(s) - medicine , lung transplantation , bronchoalveolar lavage , transplantation , lung
Simkania negevensis infection has been hypothesized to play a role in lung transplant rejection. The incidence of S. negevensis infection and its association with acute cellular rejection ( ACR ) were determined in a prospective cohort study of 78 lung transplant recipients ( LTR s) in Toronto, Canada, and Pittsburgh, USA , from July 2007 to January 2010. Simkania negevensis testing was detected by quantitative polymerase chain reaction ( PCR ) on bronchoalveolar lavage fluid. The relationship between S. negevensis and ACR was examined using Cox proportional hazards models and generalized linear and latent mixed models. Cumulative incidence estimates for time‐to‐ ACR in S. negevensis PCR ‐positive vs. PCR ‐negative LTR s were 52.7% vs. 31.1% at six months and 68.9% vs. 44.6% at one yr, respectively. Although not statistically significant, there was a trend toward a higher risk of ACR among S. negevensis PCR ‐positive vs. PCR ‐negative LTR s in all statistical models.