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Influence of recipient age on deceased donor kidney transplant outcomes in the expanded criteria donor era
Author(s) -
AlShraideh Yousef,
Farooq Umar,
Farney Alan C.,
Palanisamy Amudha,
Rogers Jeffrey,
Orlando Giuseppe,
Buckley Michael R.,
ReevesDaniel Amber,
Doares William,
Kaczmorski Scott,
Gautreaux Michael D.,
Iskandar Samy S.,
Hairston Gloria,
Brim Elizabeth,
Mangus Margaret,
Stratta Robert J.
Publication year - 2014
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12463
Subject(s) - medicine , incidence (geometry) , retrospective cohort study , renal function , surgery , single center , kidney , kidney transplantation , kidney transplant , urology , physics , optics
Methods We performed a retrospective single‐center review of 884 deceased donor ( DD ) kidney transplants ( KT s) in patients (pts) aged ≥40 yr. Results One hundred and four (11.8%) pts were ≥70 (mean 74), 286 (32.3%) were 60–69 (mean 64), and 494 (55.9%) were 40–59 (mean 51) yr of age; the proportion receiving expanded criteria donor ( ECD ) kidneys were 66%, 49%, and 30%, respectively (p < 0.001). Mean waiting time (15 months) was shorter for pts ≥70 yr compared to the other two groups combined (23 months, p = 0.002). With mean follow‐up ranging from 54 to 70 months, actual pt (81% vs. 72%, p = 0.002) and graft (66% vs. 58.5%, p = 0.03) survival rates were higher in the younger compared to the two older groups, whereas death‐censored graft survival was similar (76% vs. 73%, p = NS). The incidence of death with a functioning graft correlated with older recipient age group, increasing from 13% to 18% to 23% (p = 0.01). The incidence of delayed graft function was similar (31.8% overall), and renal function, morbidity, and resource utilization were similar among groups. Conclusions By directing ECD kidneys to selected older pts, waiting times are reduced and censored survival outcomes are similar to middle‐aged patients, suggesting that matching strategies for graft and patient lifespan are warranted.