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Uric acid and clinical correlates of endothelial function in kidney transplant recipients
Author(s) -
Dahle Dag Olav,
Jenssen Trond,
Holdaas Hallvard,
Åsberg Anders,
Soveri Inga,
Holme Ingar,
Mjøen Geir,
Eide Ivar A.,
Pihlstrøm Hege,
Dörje Christina,
Halden Thea A. S.,
Hartmann Anders
Publication year - 2014
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12435
Subject(s) - medicine , uric acid , brachial artery , reactive hyperemia , endothelial dysfunction , renal function , endothelium , cardiology , kidney transplantation , stepwise regression , transplantation , blood pressure , blood flow
Uric acid is associated with increased mortality in kidney transplant recipients (KTRs), but it is uncertain if this involves endothelial dysfunction. We hypothesized, first, that there was an association between uric acid and endothelial function, and second, that there were associations between endothelial function and cardiac and mortality risk scores. Methods One hundred and fifty‐two patients were examined 10 wk after kidney transplantation by two measures of endothelial function, the brachial artery flow‐mediated dilatation ( FMD ) expressed as percent dilatation ( FMD %), and fingertip peripheral arterial tone (PAT) expressed as log‐reactive hyperemia index (Ln RHI ). Risk scores were calculated from a recently validated formula. Other clinical correlates of endothelial function were described in stepwise linear regression models. Results Uric acid was associated negatively with FMD % in an age‐ and gender‐adjusted model, while not in the multivariable model. No association was shown between uric acid and Ln RHI . FMD % was associated negatively with risk scores in both crude and age‐ and gender‐adjusted models (p < 0.01). Ln RHI was associated negatively with risk scores in the latter model only (p < 0.05). Conclusions Uric acid was neither associated with FMD % nor Ln RHI in KTRs. There were significant associations between endothelial function indices and cardiac and mortality risk scores.