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Multiorgan transplantation from a deceased donor with intravascular diffuse large B ‐cell lymphoma: transmission of the disease and results of treatment
Author(s) -
Dziewanowski Krzysztof,
Drozd Radosław,
Parczewski Miłosz,
Klinke Małgorzata
Publication year - 2014
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12417
Subject(s) - medicine , malignancy , transplantation , lymphoma , chemotherapy , organ transplantation , disease , pathology , surgery
This report presents the transplantation of two kidneys and the liver from a deceased donor with suspected autoimmune encephalomeningitis ( ADEM ). Due to an atypical post‐transplantation clinical course, the transplanted kidneys were biopsied and this disclosed diffuse large B‐cell ( DLBC ) lymphoma of the intravascular type in each kidney. The same malignancy was found in the postmortem donor brain examination. The renal allografts from the two recipients were removed: despite every effort, one patient died, while chemotherapy was successful in the second. No malignancy was observed in the liver transplant recipient, who received prophylactic chemotherapy. These cases highlight the occasional failure of organ donor disease screening and the consequent unforeseen complications.