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Risk of serious gastrointestinal bleeding in living kidney donors
Author(s) -
Thomas Sonia M.,
Lam Ngan N.,
Huang Anjie,
Nash Danielle M.,
Prasad G. V.,
Knoll Gregory A.,
Koval John J.,
Lentine Krista L.,
Kim S. Joseph,
Alam Ahsan,
Lok Charmaine E.,
Treleaven Darin J.,
Garg Amit X.
Publication year - 2014
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12344
Subject(s) - medicine , hazard ratio , gastrointestinal bleeding , cohort , retrospective cohort study , donation , confidence interval , cohort study , kidney transplantation , renal function , population , surgery , kidney , environmental health , economics , economic growth
Individuals with moderate‐to‐severe reduced renal function have greater risk of gastrointestinal bleeding than those with normal renal function. We conducted a retrospective matched cohort study to assess whether living kidney donors share a similar risk. We reviewed pre‐donation charts for living kidney donations from 1992 to 2009 in Ontario, Canada, and linked this information to healthcare databases. We selected healthy non‐donors from the general population and matched ten non‐donors to every donor. Of the 2009 donors and 20 090 matched non‐donors, none had evidence of gastrointestinal bleeding prior to cohort entry. The cohort was followed for a median of 8.4 yr (maximum 19.7 yr; loss to follow‐up <7%). There was no significant difference in the rate of hospitalization with gastrointestinal bleeding in donors compared to non‐donors (18.5 vs. 14.9 events per 10 000 person‐years; rate ratio 1.24; 95% confidence interval [CI] 0.85–1.81). Similar results were obtained when we assessed the time to first hospitalization with gastrointestinal bleeding (hazard ratio 1.25, 95% CI 0.87–1.79). In conclusion, we found living kidney donation was not associated with a higher risk of hospitalization with gastrointestinal bleeding. These results are reassuring for the safety of the practice.