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Endothelial nitric oxide synthase polymorphism influences renal allograft outcome
Author(s) -
Uyar Murathan,
Sezer Siren,
Ozdemir Fatma Nurhan,
Kulah Eyup,
Arat Zubeyde,
Atac Fatma Belgin,
Haberal Mehmet
Publication year - 2014
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12302
Subject(s) - enos , medicine , gene polymorphism , allele , transplantation , endocrinology , nitric oxide synthase , gastroenterology , nitric oxide , gene , genetics , biology
Background Atherosclerotic lesions within the graft are considered to be a major cause of interstitial fibrosis/tubular atrophy (IF/TA). We evaluated the factors that influence the development of IF/TA and three‐ and five‐yr graft survival including nitric oxide synthase ( eNOS ) and angiotensin II type 1 and type 2 receptor gene polymorphism. Methods Seventy‐one male and 35 female patients (age: 34.9 ± 11.2 yr) who underwent living‐related renal transplantation were included. Angiotensin type 1 and type 2 receptor gene polymorphisms and eNOS intron 4 gene polymorphism were analyzed. The pre‐ and post‐transplant laboratory data, patient characteristics, acute rejection episodes, and presence of IF/TA were evaluated. Results Patients with the bb allele of eNOS gene had a lower prevalence of post‐transplant third year (12.6% and 38.5%, p = 0.005) and fifth year IF/TA (46.6% and 82.3%, p = 0.02) and a lower incidence of five‐yr graft failure (35.4% and 55.6%, p < 0.005). The eNOS gene polymorphism was independent and was the most prominent factor associated with third and fifth year IF/TA (p = 0.01, RR: 29.72, and p = 0.03, RR: 4.1, respectively). No significant relationship existed when angiotensin II gene polymorphisms were considered. Conclusions We concluded that recipient eNOS gene polymorphism can predict IF/TA, and the presence of the bb allele is associated with better graft outcome.