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Outcomes of kidney allograft in recipients with kidney disease of unknown etiology
Author(s) -
Kim Hyo Jin,
Kim Hyunsuk,
Cho Hyun Seop,
Hwang Jin Ho,
Jung In Mok,
Ahn Curie,
Ha Jongwon,
Oh Yun Kyu,
Lim Chun Soo,
Chae DongWan,
Kim Yon Su,
Lee Jung Pyo
Publication year - 2013
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12247
Subject(s) - medicine , etiology , transplantation , kidney transplantation , nephropathy , incidence (geometry) , kidney disease , kidney , gastroenterology , glomerulonephritis , cumulative incidence , chronic allograft nephropathy , urology , surgery , diabetes mellitus , endocrinology , physics , optics
The etiology of renal disease is important because the primary renal pathology may affect the outcomes of kidney allograft with respect to recurrence, rejection, and survival. However, for a significant number of patients who undergo kidney transplantation, the disease etiology is unknown. Here, allograft outcomes for patients with kidney disease of unknown etiology ( UEK ) at three affiliated K orean hospitals were identified. The incidence of biopsy‐proven acute rejection ( BPAR ) for UEK was 22.9%, which was similar to the rates for diabetic nephropathy ( DN , 24.4%) and IgA nephropathy ( IgAN , 20.0%; p = 0.345). The cumulative incidence of post‐transplant glomerulonephritis ( PTGN ) among patients with UEK was significantly lower than that among patients with IgAN (p < 0.001). Overall graft survival of the UEK group was superior to that of the DN group (hazards ratio 0.39, 95% confidence interval 0.17–0.92, p = 0.030). Preemptive transplantation for UEK significantly reduced the incidence of BPAR (preemptive vs. non‐preemptive 9.6% vs. 30.3%, p = 0.001), but graft survival and recurrence were not affected by preemptive transplantation. The outcomes of kidney transplantation for patients with UEK were not inferior to those for patients with IgAN or DN . Preemptive kidney transplantation may be encouraged for UEK patients.