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A two‐yr prospective study of bone health in children after renal transplantation employing two imaging techniques
Author(s) -
Christoforidis Athanasios,
Printza Nikoleta,
Gkogka Chrysa,
Kazantzidou Eirini,
Papachristou Fotios
Publication year - 2013
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12206
Subject(s) - medicine , bone mineral , femoral neck , urology , transplantation , dual energy x ray absorptiometry , prospective cohort study , tibia , renal function , nuclear medicine , surgery , osteoporosis
The aim of this study was to prospectively and longitudinally evaluate bone properties with the use of two bone imaging techniques (dual energy X‐ray absorptiometry [ DXA ], and quantitative ultraSonography [QUS]) in pediatric renal transplant recipients. Fourteen patients (eight boys and six girls) with a mean age of 12.25 ± 3.11 yr (range: 8–17.5 yr) completed a two‐yr follow‐up. Measurements of bone mineral density ( BMD ) by DXA at lumbar spine and hip and speed of sound ( SOS ) by QUS at radius and tibia were performed at the beginning and at the end of the study. A significant improvement in mean Z ‐score of SOS values measured at tibia (1.01 ± 1.31 vs. −0.46 ± 1.14, p = 0.005) was observed. On the contrary, mean Z ‐score of BMD values measured at femoral neck was significantly reduced (−1.95 ± 2.15 vs. −0.33 ± 1.13, p = 0.041). Finally, multivariate stepwise regression analyses showed that glomerular filtration rate at the beginning of the study was the best predictor of the difference in BMD Z ‐scores measured at lumbar spine. Additionally, values of intact parathormone ( iPTH ) at the beginning of the study and the change in iPTH throughout the study predicted the 72.3% of the difference in Z ‐score of SOS measured at radius with an inverse relationship.