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Time‐in‐a‐bottle ( TIAB ): a longitudinal, correlational study of patterns, potential predictors, and outcomes of immunosuppressive medication adherence in adult kidney transplant recipients
Author(s) -
Russell Cynthia L.,
Ashbaugh Catherine,
Peace Leanne,
Cetingok Muammer,
Hamburger Karen Q.,
Owens Sarah,
Coffey Deanna,
Webb Andrew W.,
Hathaway Donna,
Winsett Rebecca P.,
Madsen Richard,
Wakefield Mark R.
Publication year - 2013
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12203
Subject(s) - medicine , kidney transplant , medication adherence , kidney transplantation , longitudinal study , psychological intervention , kidney disease , analysis of variance , explained variation , transplantation , psychiatry , pathology , machine learning , computer science
This study examined patterns, potential predictors, and outcomes of immunosuppressive medication adherence in a convenience sample of 121 kidney transplant recipients aged 21 yr or older from three kidney transplant centers using a theory‐based, descriptive, correlational, longitudinal design. Electronic monitoring was conducted for 12 months using electronic monitoring. Participants were persistent in taking their immunosuppressive medications, but execution, which includes both taking and timing, was poor. Older age was the only demographic variable associated with medication adherence ( r = 0.25; p = 0.005). Of the potential predictors examined, only medication self‐efficacy was associated with medication non‐adherence, explaining about 9% of the variance ( r = 0.31, p = 0.0006). The few poor outcomes that occurred were not significantly associated with medication non‐adherence, although the small number of poor outcomes may have limited our ability to detect a link. Future research should test fully powered, theory‐based, experimental interventions that include a medication self‐efficacy component.