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Latent I g A deposition from donor kidneys does not affect transplant prognosis, irrespective of mesangial expansion
Author(s) -
Sofue Tadashi,
Inui Masashi,
Hara Taiga,
Moritoki Masahiro,
Nishioka Satoshi,
Nishijima Yoko,
Moriwaki Kumiko,
Hayashida Yushi,
Ueda Nobufumi,
Kushida Yoshio,
Haba Reiji,
Nishiyama Akira,
Kakehi Yoshiyuki,
Kohno Masakazu
Publication year - 2013
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12158
Subject(s) - medicine , transplantation , kidney transplantation , kidney , renal function , urology
Latent mesangial immunoglobulin A ( I g A ) deposition in the donated kidney has been investigated in the context of kidney transplantation. However, few studies have examined the impact of mesangial expansion accompanied with I g A deposition. Therefore, we investigated the effects of latent I g A deposition and mesangial expansion on transplant prognosis following living‐donor kidney transplantation. Methods We retrospectively analyzed 68 consecutive adult living‐donor kidney transplantations performed at K agawa U niversity H ospital. Biopsies were performed at pre‐implantation and at one yr after transplantation. Results Twenty kidneys exhibited latent I g A deposition in pre‐implantation biopsies, including 14 with mesangial expansion. Latent I g A deposition was not associated with renal function or donor urinalysis after donation, irrespective of mesangial expansion. Latent I g A deposition was not significantly associated with graft survival rate, allograft function, abnormal urinalysis, or the recurrence of I g A nephropathy, irrespective of mesangial expansion. At one yr after transplantation, I g A deposition had disappeared in 14/20 allografts. Estimated glomerular function rate >40 mL/min/1.73 m 2 was significantly associated with the disappearance of I g A deposition. Conclusions The present study showed that latent I g A deposition from the donor kidney, irrespective of mesangial expansion, does not affect transplant prognosis following living‐donor kidney transplantation.