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Serum albumin level during intestinal exfoliative rejection: a potential predictor of graft recovery and patient outcome
Author(s) -
Zambernardi Agustina,
Gondolesi Gabriel,
Cabanne Ana,
Martinez María I.,
Solar Héctor,
Rumbo Martín,
Rumbo Carolina
Publication year - 2013
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12078
Subject(s) - medicine , gastroenterology , complication , albumin , retrospective cohort study , cohort , transplantation , serum albumin , surgery
Abstract Exfoliative rejection is a severe complication after intestinal transplant. The assessment of mucosa histology is restricted to the area reached by endoscopy. We aim to evaluate the serum albumin ( SA ) value as a parameter of graft damage and clinical prognosis in intestinal exfoliative rejection ( E x R ). The present study is a retrospective analysis of 11 episodes of E x R occurred in a cohort of 26 patients. SA levels were measured 24 h after diagnosis and twice a week thereafter and then correlated with parameters of clinical and graft histological recovery ( HR ). During E x R , all patients had very low SA levels, reaching a minimum average of 1.9 ± 0.3 g/dL. According to the value of albumin levels at E x R diagnosis, the patients were grouped finding a correlation with their clinical evolution. Six E x R episodes presented with severe hipoalbuminemia (<2.2 g/dL; p < 0.05) that correlated with worse patient and graft outcome, ranging from graft loss and need for re‐transplantation to delayed clinical and HR . SA at E x R diagnosis may be an indicator of the severity of the E x R process, and it could also be used as an early predictor of patient and graft outcome.