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Effects of immunosuppressive agents on T h17 cells involved in transplantation
Author(s) -
Wang XiaoFei,
van Velkinburgh Jennifer C.,
Zhang Yi,
Ni Bing,
Yang ZhanYu
Publication year - 2012
Publication title -
clinical transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.918
H-Index - 76
eISSN - 1399-0012
pISSN - 0902-0063
DOI - 10.1111/ctr.12043
Subject(s) - medicine , immunology , immune system , t cell , transplantation , cytokine , proinflammatory cytokine , t lymphocyte , immunosuppression , inflammation
The lymphocyte‐derived helper T ( T h) cells are critical regulators of the adaptive immune response and are associated with inflammatory disease. The most recently recognized T h‐cell lineage, T h17, plays an important role in host defense against extracellular pathogens by secreting the proinflammatory cytokine, interleukin 17, and recruiting reactive oxygen species ( ROS )‐producing monocytes to the site of infection. However, accumulating evidence has implicated T h17‐cell dysregulation as an underlying cause for some immune‐related pathogenic conditions, including allograft rejection. Recent studies of human transplant patients have indicated that T h17 cells exhibit resistance to current immunosuppressive therapies that would otherwise prevent allograft rejection. In this review, we will discuss the most current research findings related to T h17‐cell function in various kinds of allografts.