Open AccessThe relation between distant metastasis and genetic change type in stage IV lung adenocarcinoma patients at diagnosis
Author(s) -
Ermin Sinem,
Batum Özgür,
Saka Güvenç Merve,
Diniz Gülden,
Ayrancı Aysu,
Erdoğan Kadri Murat,
Yücel Nur,
Yıldırım Eylem,
Özdemir Taha Reşid,
Hacar Alev Gülşah,
Güldaval Filiz,
Koç Altuğ,
Aydoğdu Zekiye,
Balcı Günseli,
Özyılmaz Berk,
Akşit Yaşar Hacer,
Özer Kaya Özge,
Gayaf Mine,
Kırbıyık Özgür,
Aksel Nimet,
Kutbay Yaşar Bekir,
Ursavaş Tuba Nihal,
Karadeniz Gülistan,
Polat Gülru,
Kömürcüoğlu Berna,
Çırak Ali Kadri,
Yılmaz Ufuk
Publication year - 2021
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.13284
Subject(s) - medicine , adenocarcinoma , anaplastic lymphoma kinase , metastasis , lung , oncology , stage (stratigraphy) , lung cancer , brain metastasis , gastroenterology , cancer , biology , paleontology , malignant pleural effusion
Brain metastasis prevalence is higher in patients with positive epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) and C‐ROS oncogene 1 (ROS‐1) fusion change in lung adenocarcinoma. Objectives The purpose of our study is to investigate the relation between the genetic change type and the initial distant metastasis in stage IV lung adenocarcinoma patients with genetic changes. Methods The study was conducted between January 2007 and December 2018 in a retrospective fashion with patients who had lung cancer diagnosed as stage IV adenocarcinoma. The relation between genetic mutation change (EGFR, ALK or ROS‐1) and distant metastasis was analysed. Results A total of 845 patients were included in the study. The median age was 62 (28‐88). It was determined that lung and pleura metastases were more frequent at a significant level in patients with positive EGFR mutation ( P = 0.032, P = 0.004, respectively). In patients with positive ALK fusion change, pleura metastasis was determined to be more frequent ( P = 0.001). Multiple metastases were determined to be significantly more in patients with positive ALK fusion change than single metastasis ( P = 0.02). Conclusion In patients with EGFR mutant lung adenocarcinoma, lung and pleura metastasis is more frequent and pleura metastasis is more frequent in ALK positive adenocarcinoma. Additionally, multiple organ metastases are higher in ALK positive lung adenocarcinoma.