Open AccessThiol‐disulfide as a novel indicator of obstructive sleep apnea
Author(s) -
Argüder Emine,
Parlak Ebru Ş.,
Kılıç Hatice,
Hezer Habibe,
Neşelioğlu Salim,
Hasanoğlu Hatice Canan,
Yalçıner Gökhan,
Babademez Mehmet Ali,
Erel Özcan
Publication year - 2020
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.13180
Subject(s) - thiol , obstructive sleep apnea , oxidative stress , homeostasis , medicine , endocrinology , biochemistry , chemistry
Obstructive sleep apnea (OSA) is an oxidative stress disease, which has been considered to be a notable risk and associated with increased cardiovascular morbidity and mortality. Thiol‐disulfide homeostasis is as a novel indicator of oxidative stress. Objectives We aimed to evaluate thiol‐disulfide homeostasis in a large patient population with OSA. Methods A total of 230 with OSA and 40 healthy controls were included in the study. Inclusion criteria for OSA patients are having apnoea‐hypopnoea index of ≥5/hour, being more than 18 years of age and having no previous treatment for OSA. Thiol‐disulfide analysis was done for the patients and control group. Blood thiol‐disulfide homeostasis was analysed using the new automatic method, developed by Erel and Neşelioğlu. Results Among all OSA subjects, 149 (64.8%) were males and the mean ages of the patients were 53.38 ± 10.22. Total thiol, native thiol (SH) and disulfide (SS) levels were significantly lower in OSA group compared to the control group ( P < .001, P < .001 and P = .039 respectively). Also, total thiol and native thiol (SH) were significantly different between the groups according to OSA severity (mild‐moderate to severe OSA) ( P < .001 and P < .001 respectively). Thiol‐disulfide redox parameters were correlated with apnoea‐hypopnoea index (AHI) scores. Conclusion The present prospective study showed that thiol/disulfide homeostasis was unbalanced in OSA patients. Especially, in OSA patients have low level of thiol/disulfide redox parameters when compared to healthy subjects. Evaluating thiol‐disulfide homeostasis in OSA may be a contributing aspect to assessment and monitoring of the patient.