Open AccessFeasibility of ultrasound‐assisted catheter‐directed thrombolysis for submassive pulmonary embolism: A meta‐analysis of case series
Author(s) -
Wu Jiayan,
Chen Haiming,
Yu Yongqin,
Peng Lingsheng,
Li Jieying,
Liang Hengrui,
Ba Manqing,
Ruan Honglian,
Hong Cheng
Publication year - 2020
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.13155
Subject(s) - medicine , meta analysis , pulmonary embolism , cochrane library , thrombolysis , pulmonary artery catheter , medline , pulmonary artery , cardiology , radiology , hemodynamics , myocardial infarction , cardiac output , political science , law
Background During the past few years, there has been a surge in the use of ultrasound‐assisted catheter‐directed thrombolysis (UACDT) for submassive pulmonary embolism (SPE). However, few studies evaluated the feasibility of UACDT for SPE.Purpose To evaluate the feasibility of UACDT in treating SPE. Methods A comprehensive search of online databases was performed. Search terms UACDT in SPE were entered into PubMed, Embase, Scopus and the Cochrane Library to identify related articles published until October 2018. A quality assessment and data extraction were performed by two researchers. Meta‐analysis was performed using R statistical software. Results Twelve studies with 485 patients were included in this meta‐analysis. The pooled right ventricular/left ventricular ratio decrease and pulmonary artery systolic pressure drop after treatment was −0.34 (95% CI: −0.43, −0.25) and −15.05 (95% CI: −18.10, −12.00) mm Hg, respectively. The pooled major bleeding rate was 1.0% (95% CI: 0.0%, 3.0%), and the in‐hospital mortality was 0.0% (95% CI: 0.0%, 1.0%). Conclusion This up to data meta‐analysis confirms that UACDT is a feasible treatment for SPE.