Open AccessThe clinical characteristics and prognosis of ABPA are closely related to the mucus plugs in central bronchiectasis
Author(s) -
Lu HaiWen,
Mao Bei,
Wei Ping,
Jiang Sen,
Wang Hong,
Li ChengWei,
Ji XiaoBing,
Gu ShuYi,
Yang JiaWei,
Liang Shuo,
Cheng KeBin,
Bai JiuWu,
Cao WeiJun,
Jia XinMing,
Xu JinFu
Publication year - 2020
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.13111
Subject(s) - medicine , bronchiectasis , sputum , allergic bronchopulmonary aspergillosis , mucus , radiological weapon , gastroenterology , lung , pathology , immunology , radiology , tuberculosis , immunoglobulin e , ecology , antibody , biology
The characteristics of Allergic Bronchopulmonary Aspergillosis (ABPA) based on its radiological classification is still unclear. Objectives To investigate the clinical significances of ABPA patients with central bronchiectasis (ABPA‐CB) by different radiological classifications of mucus plugs. Methods ABPA‐CB patients from a pulmonary hospital between 2008 and 2015 were retrospectively included and analysed. According to the chest imaging in their first visit to physician, the ABPA‐CB patients were divided into two groups based on the presence of high‐attenuation mucus (HAM) or low‐attenuation mucus (LAM). The primary endpoint was ABPA relapse within 1 year since the glucocorticoid withdrawal. The relationship between the imaging findings and the clinical prognosis was illuminated. Results A total of 125 ABPA patients were analysed in this study. Compared to the LAM group, the HAM group presented higher blood eosinophil cells counts, higher rates of Aspergillus detection isolated in sputum and expectoration of brownish‐black mucus plugs, more affected lobes and segments, poorer pulmonary function and higher rate of relapse. Conclusions The clinical characteristics and prognosis of ABPA‐CB patients are closely related to its radiological phenotype of mucus plugs in the central bronchiectasis. Clinicians should promote a diversity of personalized treatments for different patients with different radiological characteristics.