Open AccessPrognostic significance of preoperative consolidation to maximum tumour diameter ratio and SUVmax in pathological stage I lung adenocarcinoma
Author(s) -
Akın Kabalak Pınar,
Yılmaz Ülkü,
Ertürk Hakan,
Özmen Özlem,
Demiröz Şevki Mustafa,
Demirağ Funda,
Kızılgöz Derya,
Kavurgacı Suna,
İnal Cengiz Tuba
Publication year - 2020
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.13102
Subject(s) - medicine , adenocarcinoma , pathological , t stage , stage (stratigraphy) , lung , pathological staging , gastroenterology , multivariate analysis , oncology , overall survival , cancer , paleontology , biology
Objectives Consolidation/tumour ( C / T ) ratio means the maximum diameter of the consolidation is divided by the maximum diameter of the tumour and it is predictive for pathologic subtypes and prognosis after resection of the tumour. The purpose of this study is to clarify impact of C / T ratio along with maximum standardized uptake value (SUV) in pathological stage I lung adenocarcinoma. Methods Only patients with pathological stage I lung adenocarcinoma diagnosed by resection were included. Prognostic impact of C / T ratio and SUVmax were analysed by using regression analyses. Results Totally 156 patients (121 males, 35 females) were evaluated retrospectively. Overall survival (OS) and progression free survival (PFS) were higher in patients with C / T ratio ≥0.5 (OS: 46.3 ± 23.7 vs 30.4 ± 14.6, P = 0.002 and PFS: 43.0 ± 25.4 vs 27.8 ± 15.8, P = 0.005). But PFS and OS curves did not reveal any significant differences with Kaplan‐Meier method ( P = 0.45 and P = 0.055 respectively). Resection type (limited vs anatomic) and C / T ratio were predictors for OS in multivariate analyses (resection type: HR: 2.21 (1.01‐4.83), P = 0.045 and C / T ratio: HR: 0.44 (0.20‐0.98), P = 0.045). For PFS, resection type and SUVmax had prognostic significance (resection type: HR: 3.56 (1.64‐7.74), P = 0.001 and SUVmax: HR: 1.31 (0.82‐2.99), P = .002). Conclusion In pathological stage 1 lung adenocarcinomas, SUVmax and surgery type are important predictors for recurrence rates. For early stage, adenocarcinoma patients with high SUVmax value, tumour size ≥3 cm and high grade subtype, C / T ratio should not be considered significant alone on survival and recurrence.