Open AccessA case‐control study of the genetic polymorphism of IL6 and HAPE risk in a Chinese Han population
Author(s) -
He Xue,
Wang Li,
Zhu Linhao,
Yuan Dongya,
He Yongjun,
Jin Tianbo
Publication year - 2018
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12922
Subject(s) - medicine , odds ratio , single nucleotide polymorphism , han chinese , confidence interval , logistic regression , genotype , case control study , polymorphism (computer science) , gene , genetics , biology
Aims The role of inflammatory cytokines in High‐altitude pulmonary edema (HAPE) remains unclear. The purpose of this study was to evaluate the role of IL4 and IL6 gene polymorphism in the development of HAPE in Chinese people. Methods In the present study, we screened ten polymorphisms of IL4 and IL6 gene in 265 HAPE and 303 healthy volunteers. Genotypes were determined using the Sequenom MassARRAY method. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression. Results Two single‐nucleotide polymorphisms (SNPs) in the IL6 gene were significantly associated with HAPE. Rs1800796 and rs1524107 (G vs C, OR = 1.31, 95%CI = 1.01‐1.69, P = .041 and T vs C, OR = 1.35, 95%CI = 1.05‐1.74, P = .020, respectively). However, there did not found any association for IL4 gene. Conclusion Inflammatory cytokines may play a role in the progress of HAPE. These polymorphisms could be genetic markers for predicting the susceptibility to HAPE.