Open AccessDoes advanced lung inflammation index (ALI) have prognostic significance in metastatic non‐small cell lung cancer?
Author(s) -
Ozyurek Berna Akinci,
Ozdemirel Tugce Sahin,
Ozden Sertac Buyukyaylaci,
Erdoğan Yurdanur,
Ozmen Ozlem,
Kaplan Bekir,
Kaplan Tugba
Publication year - 2018
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12768
Subject(s) - medicine , lung cancer , gastroenterology , hazard ratio , body mass index , proportional hazards model , cancer , oncology , inflammation , confidence interval
Background Lung cancer is the most commonly diagnosed and death‐related cancer type and is more frequent in males. Non‐small‐cell lung cancer (NSCLC) accounts for about 85% of all case. In this study, it was aimed to research the relationship between advanced lung inflammation index (ALI) and the primary mass maximum standardized uptake value (SUVmax) and C‐reactive protein (CRP) at initial diagnosis and the prognostic value of ALI in determining the survival in metastatic NSCLC. Methods A total of 112 patients diagnosed as stage 4 non‐small‐lung cancer in our hospital between January 2006 and December 2013 were included in this study. ALI was calculated as body mass index (BMI) × serum albumin/neutrophil‐to‐lymphocyte ratio (NLR). The patients were divided into two groups as ALI < 18 (high inflammation) and ALI ≥ 18 (low inflammation). The log‐rank test and Cox proportional hazard model were used to identify predictors of mortality. Results Evaluation was made of 94 male and 18 female patients with a mean age of 59.7 ± 9.9 years. A statistically significant negative relationship was determined between ALI and CRP values ( P < .001), but no relationship was found between ALI and SUVmax values ( P = .436). The median survival time in patients with ALI < 18 was 12 months and, in those with ALI ≥ 18, it was 16 months ( P = .095). Conclusion ALI is an easily calculated indicator of inflammation in lung cancer patients. Values <18 can be considered to predict a poor prognosis.