Open AccessChanges in inflammatory mediators as a result of intermittent hypoxia in obstructive sleep apnea syndrome
Author(s) -
Sozer Volkan,
Kutnu Müge,
Atahan Ersan,
Calıskaner Ozturk Buket,
Hysi Ergi,
Cabuk Cansu,
Musellim Benan,
Simsek Gonul,
Uzun Hafize
Publication year - 2018
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12718
Subject(s) - medicine , obstructive sleep apnea , polysomnography , procalcitonin , gastroenterology , apnea–hypopnea index , inflammation , sleep apnea , systemic inflammation , hypoxia (environmental) , apnea , chemistry , organic chemistry , oxygen , sepsis
Background Inflammation plays an important role in obstructive sleep apnea syndrome (OSAS). The objective of this study was to investigate the relationship of serum C‐reactive protein (CRP), pentraxin‐3 (PTX‐3), procalcitonin (ProCT), interleukin‐33 (IL‐33) and its soluble receptor ST2 (sST2) with the syndrome severity and to show theirs importance as biomarkers. Methods This study comprises a total of 84 identical (sex and age wise) cases. Full‐night polysomnography was performed in each patient. OSAS diagnosis and severity index being based on the widely used criterion known as Apnea Hypopnea Index(AHI). Subgroups were as follows: 24(AHI < 5) controls, 28 mild‐moderate OSAS(AHI 5–30) and 32 severe OSAS(AHI > 30). Results PTX‐3, IL‐33 and sST2 receptors were significantly higher in OSAS groups than the control group ( P < .001). However, both CRP and ProCT levels were similar in all subjects. There was a positive correlation between PTX‐3 and BMI ( r = 0.446; P < .01), ODI ( r = 0.555; P < .01), IL‐33 ( r = 0.348; P = .001) and sST2 ( r = 326; P = .002), while there was a negative correlation with minimum SaO 2 ( r = −0.672; P < .01) in patient group. PTX‐3 as a predictor of OSAS showed highest specificity (%91.7) and sensitivity (%91.7) ( P < .001). Conclusions PTX‐3 can be a new indicator reflecting the inflammatory state in patients with OSAS. Since patients with OSAS could have more hypoxic state during sleep, we found higher PTX‐3 level in those patients and a negative correlation between PTX‐3 and minimum SaO 2 , which could explain that PTX‐3 levels can increase with the severity of disease. Our results suggest that PTX‐3 as an inflammatory biomarker may play a crucial role as an indicator of syndrome severity in OSAS.