Open AccessAirflow obstruction, cognitive function and mortality in a US national cohort: NHANES‐III
Author(s) -
Odeyemi Yewande E.,
Meda Edris,
Ogundipe Funmilola,
Russ Ebony,
Mehari Alem,
Obisesan Thomas,
Gillum Richard F.
Publication year - 2018
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12643
Subject(s) - medicine , vital capacity , hazard ratio , proportional hazards model , national health and nutrition examination survey , cohort , confounding , confidence interval , gerontology , lung function , population , diffusing capacity , lung , environmental health
Objective To test the hypothesis that cognitive impairment increases mortality independent of airflow obstruction. Materials and Methods In 1988‐1994 the Third National Health and Nutrition Examination Survey (NHANES III) measured forced expiratory volume in the first second (FEV1) and the forced vital capacity (FVC) and selected items on cognitive function with mortality follow‐up. For this survival analysis 4365 persons aged 60 and over with complete data formed the analytic sample. Results The FEV1/FVC less than the lower limit of predicted ratio (LLP) defined airflow obstruction and Composite Cognitive Function Score (CCF) ≤4, cognitive impairment. The percentage who died during follow up was 67% among those with neither FEV1/FVC < LLP nor CCF ≤4, 82% with FEV1/FVC < LLP only, 85% with CCF score ≤4 only and 93% with both FEV1/FVC LLP and CCF score ≤4 ( P < .001). Weighted Cox proportional hazards regression revealed an increased hazard ratio (HR) in persons with FEV1/FVC