Open AccessPrognostic significance of ACP5 expression in patients with lung adenocarcinoma
Author(s) -
Gao YaLi,
Liu MeiRong,
Yang ShuXiang,
Dong YuJin,
Tan XiaoFeng
Publication year - 2018
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12637
Subject(s) - oncology , immunohistochemistry , medicine
Tartrate‐resistant acid phosphatase 5 ( ACP5 ), which is essential for bone resorption and osteoclast differentiation, promotes cell motility through the modulation of focal adhesion kinase phosphorylation. This study seeks to elucidate the association of ACP5 expression and the clinicopathologic characteristics of patients with lung adenocarcinoma (AD). Methods The expression of ACP5 was measured by Immunohistochemistry and Western blot analysis in lung AD and matched tumor‐adjacent tissues, and the χ 2 test was applied to analyze the correlation between ACP5 expression and clinicopathologic features. Using the Kaplan–Meier method, univariate and multivariate regression analysis was to explore the correlation between ACP5 expression and overall survival (OS). Results We found that ACP5 was frequently upregulated in lung AD tissues. The high expression of ACP5 was significantly related to lymph node status, tumor–node–metastasis (TNM) stage, and differentiation. From the results of univariate survival analysis, it indicated that the patients with high expression of ACP5 expression had a significantly lower OS than the patients with low expression of ACP5 expression. As it showed in Multivariate Cox regression analysis, the high expression of ACP5 expression was an independent prognostic factor for OS. Conclusions Our results suggest that high expression of ACP5 correlates with tumor progression and may serve as a potential prognostic biomarker in lung AD.