Open AccessAirway and sleep disorders in patients with acromegaly
Author(s) -
Turan Onur,
Akinci Barış,
Ikiz Ahmet Omer,
Itil Oya,
Oztura Ibrahim,
Ada Emel,
Akdeniz Bahri,
Yener Serkan,
Kaya Murat,
Gedik Arzu,
Comlekci Abdurrahman
Publication year - 2018
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12618
Subject(s) - medicine , acromegaly , macroglossia , tongue , polysomnography , airway , tonsil , sleep apnea , obstructive sleep apnea , apnea , anesthesia , surgery , growth hormone , pathology , hormone
Objective Acromegaly is a multisystemic disorder caused by excessive secretion of growth hormone (GH). Sleep‐disordered breathing (SDB) such as sleep apnea syndrome (SAS) may occur in acromegaly. The aim of study was to assess the presence of sleep disorders and evaluate the systemic complications on respiratory, cardiovascular, and upper airway systems in acromegalic patients. Methods The study group consisted of 30 acromegaly outpatients. GH and insulin‐like growth factor 1 (IGF‐1) measurements were obtained; body pletysmography, arterial blood gas analysis, tissue‐doppler imaging , echocardiography , polysomnography, otorhinolaryngologic examination, and head‐neck computed tomography were performed. Results Sixteen female (53.3%) and 14 male (46.7%) acromegalic patients had a mean age of 51.1 ± 13.2. GH was supressed in 19 patients (63.3%) when 11 had active acromegaly (36.7%). There were 17 patients with SAS (62.9%) (7: mild, 3:intermediate, 7:severe SAS) and average AHI was 16/h. Sixteen patients had predominantly obstructive SAS while one patient had predominantly central SAS. SAS was statistically more frequent in males than females ( P = .015). The mean neck circumference was significantly longer in patients with SAS ( P = .048). In SAS patients,the soft palate was elongated and thickened,which was statistically significant ( P = .014 and P = .05).Vallecula‐to‐tongue distance was statistically longer in acromegalic patients with SAS ( P = .007).There was a positive correlation between tonsil size,vallecula‐to‐tongue distance and AHI (r = 0.432, P = .045 and r = 0.512, P = .021, respectively). Conclusion SDB seems to be common and clinically important in patients with acromegaly, particularly in men. The most frequent type of apnea in acromegalics is obstructive. Hormonal activity of acromegaly does not seem to have an effect on the development of SAS. Despite its high prevalence, SAS is frequently under‐assessed in patients with acromegaly. Systemic complications and SDB should be researched in acromegalics.