Open AccessDifferences in inflammatory marker patterns for adult community‐acquired pneumonia patients induced by different pathogens
Author(s) -
Liu Meng,
Li Hui,
Xue Chun Xue,
Gu Li,
Qu Jiu Xin,
Yu Xiao Min,
Wang Yi Min,
Liu Ying Mei,
Cao Bin
Publication year - 2018
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12614
Subject(s) - pneumonia , medicine , bacterial pneumonia , mycoplasma pneumoniae , proinflammatory cytokine , rhinovirus , immunology , community acquired pneumonia , etiology , virus , inflammation
The inflammatory marker patterns of community‐acquired Pneumonia (CAP) induced by different microorganisms in adult patients remained unclear. Objectives We aim to explore the inflammatory marker patterns of adult CAP patients induced by different pathogens. Methods Adult CAP patients with definite etiologies were enrolled from September 2010 to June 2012. They were divided into three groups according to the causative pathogens: typical bacteria, Mycoplasma pneumoniae (MP), and viruses. Twenty‐seven cytokines and bactericidal/permeability‐increasing protein (BPI) levels of serum collected within 7 days onset in these groups were compared. Results One hundred twenty‐four cases were enrolled for serum detection and analysis, including 10 typical bacterial pneumonia patients, 56 cases with MP pneumonia and 58 with viral pneumonia. Three kinds (PDGF‐BB, IP‐10, RANTES) of 27 cytokines and BPI levels were significantly elevated in patients with acute pneumonia than healthy controls. Distinct inflammatory marker patterns were released by different pathogens: typical bacterial pneumonia patients had highest levels of BPI, IL‐6, IL‐8, IL‐1rα; while patients caused by MP presented higher levels of PDGF‐BB, IL‐17A, G‐CSF than those caused by viruses. Rhinovirus owned a higher inflammatory response level than the other viruses. The area under the curve (AUC) of PDGF‐BB to differentiate MP and virus infection was biggest, which was 0.708. Conclusion Distinct inflammatory marker patterns were released by different pathogens during acute pneumonia. Significantly increased level of PDGF‐BB was observed in acute pneumonia for the first time. It showed a better ability to differentiate MP and virus infection.