Open AccessRole of increased mean platelet volume ( MPV ) and decreased MPV /platelet count ratio as poor prognostic factors in lung cancer
Author(s) -
Omar Muhyettin,
Tanriverdi Ozgur,
Cokmert Suna,
Oktay Esin,
Yersal Ozlem,
Pilancı Kezban Nur,
Menekse Serkan,
Kocar Muharrem,
Sen Cenk Ahmet,
Ordu Cetin,
Goksel Gamze,
Meydan Nezih,
Barutca Sabri
Publication year - 2018
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12605
Subject(s) - medicine , mean platelet volume , gastroenterology , lung cancer , univariate analysis , platelet , biomarker , white blood cell , multivariate analysis , biochemistry , chemistry
Objectives In this study, they investigated whether mean thrombocyte volume (MPV) and MPV/platelet count ratio have a prognostic significance in advanced NSCLC or not. Methods A total of 496 NSCLC patients at stage IIIB/IV and did not meet exclusion criteria were included in the study. The demographic features (age, gender, smoking habit), clinical characteristics (performance status, weight loss, disease stage, first‐line treatment regimen), laboratory tests (levels of hemoglobin, lactate dehydrogenase and calcium as well as MPV, MPV/platelet count ratio and counts of white blood cell, platelet), and histological features (histologic type, tumor grade) were recorded. Results The MPV levels of all patients were determined as 10.2 {plus minus} 3.4 (range, 6.4‐14.1 fL). With ROC curve analysis, the MPV/PC ratio was associated with a sensitivity of 67.8% and a specificity of 84.8% at a cutoff value of 0.47424 for presence of brain metastasis at the time of diagnosis. Univariate analysis showed that OS was significantly shorter in the group with an increased MPV level than in the other group (median OS time 6.8 months vs. 11.5 months, log‐rank, P = .032). Multivariate analysis confirmed that an increased MPV level was an independent poor prognostic factor for OS (HR: 1.704, 95% CI: 1.274‐3.415, P = .014). Conclusions Unlike results of previous studies, the study showed that increased MPV was an important prognostic factor in patients with NSCLC. Hence, an increased MPV level may be used as a prognostic biomarker to estimate for poor overall survival in patients with NSCLC.