Open AccessThe value of prognostic factors in Chinese patients with small cell lung cancer: A retrospective study of 999 patients
Author(s) -
Hong Xuan,
Xu Qingyong,
Yang Zhaoyang,
Wang Meng,
Yang Fang,
Gao Yina,
Zhou Fengrui,
Wang Lei,
Liu Bao,
Chen Gongyan
Publication year - 2018
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12534
Subject(s) - medicine , retrospective cohort study , chemotherapy , oncology , multivariate analysis , lung cancer , proportional hazards model , performance status , univariate analysis , hyponatremia , stage (stratigraphy) , radiation therapy , regimen , lactate dehydrogenase , paleontology , biochemistry , chemistry , biology , enzyme
Little is known about the prognostic factors for small cell lung cancer (SCLC) in Chinese patients. Objective The aim of this retrospective study was to improve our understanding of overall survival (OS) and progression‐free survival (PFS) prognostic factors in Chinese patients with SCLC. Methods A retrospective analysis of 999 SCLC cases was performed. Patient characteristics, treatments, and laboratory data, including platelet counts and serum lactate dehydrogenase (LDH) and serum sodium levels, were collected. Potential prognostic factors for OS and PFS were evaluated by univariate and multivariate analyses. Results The median OS and PFS were 10.6 and 7.0 months, respectively. The multivariate Cox proportional hazards model was used to identify stage, serum LDH, and several therapy‐relevant factors, including the initial chemotherapy regimen, number of initial chemotherapy cycles, and combination therapy, as independent prognostic factors for OS. Furthermore, female sex, normal LDH levels, a response to therapy, receiving six cycles of initial chemotherapy, and receiving chemotherapy combined with radiotherapy and/or surgery were favorable prognostic factors for PFS. In addition, patients with hyponatremia had a worse OS; therefore, hyponatremia could not influence survival when a good response to therapy was achieved, and it failed to predict PFS. Conclusions This study demonstrated that several factors, including patient, tumor, and treatment characteristics and serum LDH levels are independent prognostic factors for OS and PFS in Chinese patients with SCLC. The identification of such factors will help physicians compare different populations and to interpret the contribution of treatment to differences in survival among groups.