Open AccessDiagnostic and prognostic significance of receptor‐binding cancer antigen expressed on SiSo cells in lung‐cancer‐associated pleural effusion
Author(s) -
Yang Jian,
Zhu Ying,
Wu Liangquan,
Zhu Wenyan,
Zhang Xiuwei,
Yang Yang,
Xu Chunhua
Publication year - 2018
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12527
Subject(s) - medicine , pleural effusion , malignant pleural effusion , lung cancer , univariate analysis , effusion , cancer , gastroenterology , multivariate analysis , pathology , oncology , surgery
Abstract Objectives This study aimed to evaluate the diagnostic and prognostic value of pleural effusion levels of soluble receptor‐binding cancer antigen expressed on SiSo cells (sRCAS1) in lung cancer patients with malignant pleural effusion (MPE). Methods Pleural effusion samples were collected from 78 patients with MPE, and from 48 patients with benign pleural effusion (BPE). Pleural effusion sRCAS1 concentrations were measured by enzyme‐linked immunosorbent assay. Results MPE has significantly higher sRCAS1 levels than that of BPE ( P < .01). With a cutoff value of 18.7 U/mL, sRCAS1 showed a good diagnostic performance for MPE. Univariate and multivariate analysis indicated that elevated sRCAS1 levels were an independent predictor of overall survival (OS) and disease‐free survival (DFS). Kaplan–Meier survival curves further confirmed that patients with high sRCAS1 have shorter DFS and OS ( P = .026 and P = .032, respectively). Conclusion In conclusion, measurement of sRCAS1 might be a useful diagnostic and prognostic marker for MPE.