Open AccessPulmonary fibrolysis in a patient with idiopathic pulmonary fibrosis: improvement of clinical and radiological pattern after treatment with pirfenidone
Author(s) -
Varone Francesco,
Mastrobattista Annelisa,
Franchi Paola,
Viglietta Luca,
Poletti Venerino,
Tomassetti Sara,
Dubini Alessandra,
Tagliaboschi Linda,
Calandriello Lucio,
Farchione Alessandra,
Larici Anna Rita
Publication year - 2018
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12515
Subject(s) - medicine , pirfenidone , radiological weapon , idiopathic pulmonary fibrosis , pulmonary fibrosis , radiology , fibrosis , lung
Idiopathic Pulmonary Fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia associated with the histologic and/or radiologic pattern of usual interstitial pneumonia (UIP). Nowadays, the high‐resolution computed tomography pattern of “definite UIP” is enough to define a diagnosis of UIP without histological proof. This is pivotal especially in elderly patients with comorbidities. Early recognition of IPF is relevant for its prognostic implication. Some pharmacological strategies have been proposing novel molecules that tend to slow lung function decline, even though without healing fibrosis. We report a case of ex‐heavy smoker male with IPF showing clinical and radiological improvement after 11 months of treatment with Pirfenidone. The definite diagnosis was challenging and it was reached by a multidisciplinary approach.