Open AccessAssociation between fractional exhaled nitric oxide (FeNO) cutoff values (25 ppb) and risk factors of cough
Author(s) -
Qian Ling,
Pan Shiying,
Shi Jingdong,
Du Yong,
Huang Qihui,
Jie Zhijun
Publication year - 2018
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12512
Subject(s) - medicine , exhaled nitric oxide , white blood cell , gastroenterology , eosinophil , vital capacity , asthma , etiology , immunology , chronic cough , lung , spirometry , lung function , diffusing capacity
Cough is among the most common symptoms for patients to seek medical attention. Objectives The purpose of this study is to evaluate the association between fractional exhaled nitric oxide (FeNO) cutoff values (25 ppb) and risk factors related to cough, hoping to evaluate the feasibility of the FeNO cut point values (25 ppb) for clinical prediction of cough in etiology. Methods In 107 adult patients with acute, subacute, or chronic cough, the FeNO, forced expiratory volume for 1 second (FEV1), forced vital capacity (FVC), blood routine (white blood cell and neutrophil), immunoglobulin E (IgE), lymphocyte eosinophils, and hemoglobin were measured. The Student's t ‐test was used to test the differences of FeNO levels compared with FEV1/FVC, lymphocyte, and hemoglobin level. For evaluating the correlation of FeNO levels with IgE, eosinophil, blood routine, pulmonary infection, and smoking status, the chi‐square test was performed. Results FeNO cutoff value (25 ppb) significantly correlated with serum IgE ( P < .0001) between ≥200 IU/mL and <200 IU/mL level, eosinophil ( P = .039) between ≥5% and <5% level, lymphocyte percentage ( P = .032) and the ratio of FEV1/FVC ( P = .032), while weakly correlated with pulmonary infection, blood routine (white blood cell and neutrophil), hemoglobin, and smoking. Conclusion The cutoff values of FeNO (≥25 ppb or <25 ppb) are useful for etiological detection of cough with high sensitivity.