Open AccessCould soluble urokinase plasminogen receptor (suPAR) be used as a diagnostic biomarker for ventilator‐associated pneumonia?
Author(s) -
Sunnetcioglu Aysel,
Sunnetcioglu Mahmut,
Adıyaman Fırat,
Binici Irfan,
Soyoral Lokman
Publication year - 2017
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12438
Subject(s) - supar , medicine , biomarker , pneumonia , ventilator associated pneumonia , urokinase , gastroenterology , intensive care unit , urokinase receptor , biochemistry , chemistry
Abstract Background Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker that is increasingly used for evaluation of systemic inflammation. This study was performed to investigate whether suPAR may possess a diagnostic value in patients with ventilator‐associated pneumonia (VAP). Methods This clinical study was performed in the anesthesia intensive care units (ICUs) of our university. In addition to descriptive data, WBC, serum levels of C‐reactive protein (CRP) and suPAR prior to and after development of VAP were noted and compared in 31 patients (22 men, 9 women) diagnosed with VAP (Study Group) and 19 patients without VAP (Control Group) in ICU (14 men, 5 women). Results The suPAR ( P = 0.023), CRP ( P = 0.037), WBCs ( P = 0.024) in patients with VAP were significantly higher than patients without VAP. There was no remarkable difference in terms of WBCs ( P = 0.052) and suPAR levels ( P = 0.616) between groups on the first day of connection to mechanical ventilator. The suPAR and CRP levels in patients with VAP were significantly higher than prior to development of VAP ( P = 0.001 for both). Area under curve value after diagnosis of pneumonia was found 0.248 ( P = 0.002). Conclusion To conclude, our results suggest that suPAR can be a useful diagnostic biomarker in patients with VAP. However, clinical trials on larger series are warranted to explore the clinical significance more accurately.