Open AccessCollision of lymphoepithelioma‐like carcinoma and adenocarcinoma of the lung: a case report
Author(s) -
Chan Jammy Kin Iong,
Tai Wai Meng,
Wen Jian Ming
Publication year - 2017
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12404
Subject(s) - lymphoepithelioma like carcinoma , medicine , adenocarcinoma , lung , lymph , carcinoma , magnetic resonance imaging , lymphoepithelioma , positron emission tomography , pathology , radiology , nuclear medicine , nasopharyngeal carcinoma , radiation therapy , cancer , epstein–barr virus , virus , virology
We report a rare case of collision of lymphoepithelioma‐like carcinoma (LELC) and adenocarcinoma (AC) in the lung. A 59‐year‐old woman had a history of fever and cough. A mass was found by X‐ray in the left upper lung. Magnetic resonance imaging (MRI) shows a dumbbell‐like mass in the fore and tongue segment of the left upper lung with irregular spiculate margin. Positron emission tomography/computed tomography (PET/CT) (18F‐FDG) shows strong concentration of radioactivity (SUVmax 6.9–12.3 cm) in the lung mass only. The patient subsequently underwent resection of left upper lung and associated hilar lymph nodes. Histological examination revealed it was a collision carcinoma comprising LELC and AC. The hilar lymph nodes were tumuor free. The immunoreactions, Epstein–Barr early RNA in situ hybridization and molecular analyses, such as EGFR mutation, c‐Met, anaplastic lymphoma kinase were different in both tumuor components, indicating they derived from different cell origin. This rare case was discussed.