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Acute severe asthma with thyroid crisis and myasthenia: a case report and literature review
Author(s) -
Gong PiHua,
Dong XiaoSong,
Li Chun,
Bao Jing,
Cao ZhaoLong,
Yuan Yun,
Zheng YaLi,
Gao ZhanCheng
Publication year - 2017
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12403
Subject(s) - medicine , thyroid storm , asthma , plasmapheresis , thyroid , myasthenia gravis , pediatrics , thyroiditis , intensive care medicine , immunology , antibody
Background and Aims: Acute severe asthma, thyroid crisis and acute myasthenia are all medical emergencies that rarely coexistent. Here, we report a young man with severe asthma attack, necessitate invasive mechanical ventilation at the onset, followed by thyroid crisis, rhabdomyolysis, acute kidney injury, thrombocytopenia and progressive myasthenia. The aim of this study is to better understand the relationships among severe asthma, autoimmune thyroiditis and myasthenia. Methods: The case was presented and former literatures were reviewed. Results: This is the first case report of a young patient presented with severe asthma and autoimmune thyroiditis, followed by thyroid storm, multiple organ dysfunction and myasthenia. Neither conventional treatment for asthma or thyroid storm was effective separately. The patient's clinical condition did not improve until after plasmapheresis. Conclusion: Here, we highlighted both the importance of early recognition of thyroid storm and prompt therapies, which likely attenuated organ dysfunction and enabled this patient to recover from the life‐threatening attack. Asthmatic patients should be closely controlled when suspected of thyroid disorders, especially those with high levels of anti‐thyroid antibodies irrespective of thyroid hormones concentrations.

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