Open AccessThe influence of comorbidities on mortality in sarcoidosis: a observational prospective cohort study
Author(s) -
Nowiński Adam,
Puścińska Elzbieta,
Goljan Anna,
Peradzynska Joanna,
Bednarek Michal,
Korzybski Damian,
Kamiński Dariusz,
Stokłosa Anna,
Czystowska Monika,
Śliwiński Pawel,
Górecka Dorota
Publication year - 2017
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12398
Subject(s) - medicine , sarcoidosis , comorbidity , cohort , cohort study , observational study , prospective cohort study , disease , thyroid disease , thyroid
Aim The aim of this study was to identify the frequency and prevalence of comorbidities in sarcoid patients and to assess their influence on overall mortality in the cohort of patients with sarcoidosis. Materials and methods A cohort of 557 patients with histologically confirmed sarcoidosis diagnosed between 2007 and 2011 and a group of non‐sarcoid controls were observed. All patients were carefully observed for comorbidities and mortality. Results 291 males (52.2%) and 266 females (47.8%) with mean age 48.4 ± 12.0 years in sarcoidosis group and a group of 100 controls with mean age (49.25 ± 10.3) were observed. The mean number of comorbidities in both groups was similar (0.9 ± 0.99 vs 0.81 ± 0.84 NS). The frequency of thyroid disease was significantly higher in sarcoidosis group comparing to controls at the time of diagnosis (OR = 3.62 P = 0.0144). During the observation period (median 58.0 months), 16 patients died (2.9%). The mean number of comorbidities was significantly higher in the groups of non‐survivors as compared to survivors (2.8 ± 1.0, vs 0.8 ± 0.9), P < 0.0001. Conclusion The comorbidity burden has strong impact on mortality in sarcoidosis. Thyroid diseases are more frequent in sarcoidosis than in non‐sarcoid controls.