Open AccessTotal lesion glycolysis by 18F‐FDG PET/CT is independent prognostic factor in patients with advanced non‐small cell lung cancer
Author(s) -
Yıldırım Fatma,
Yurdakul Ahmet Selim,
Özkaya Sevket,
Akdemir Ümit Özgür,
Öztürk Can
Publication year - 2017
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12391
Subject(s) - medicine , stage (stratigraphy) , lung cancer , confidence interval , multivariate analysis , retrospective cohort study , lesion , cancer , nuclear medicine , oncology , radiology , pathology , paleontology , biology
Background and Aims To determine whether the primary tumor SUVmax and total lesion glycolysis (TLG) measured on 18 F‐FDG PET/CT have prognostic significance in patients with non–small‐cell lung cancer (NSCLC). Methods A retrospective review identified 142 patients NSCLC who underwent 18 F‐FDG PET/CT at the time of diagnosis. The affect of the SUVmax and TLG of the primary tumor on survival were examined. Results Total 142 patients were included the study. Thirty‐two patients were at early stage (stage I and II) and 110 patients were at advanced stage (stage III and IV). Both early and advanced stage patients were divided into two groups according to SUVmax 12 as low and high SUVmax groups. Overall survival (OS) of the low SUVmax group was significantly longer than higher SUVmax group for early‐stage patients (35.8 ± 15.3 vs 21.8 ± 13.3, P = 0.013). But there was no differences in advanced stage patients for OS (16.1 ± 14.8 vs 17.0 ± 15.1, P = 0.862). Primary lesion TLG of the 99 patients were calculated. For advanced stage, the patients with the lower TLG had significantly longer survival time ( P < 0.001). In multivariate analysis only TLG remained significant predictor of OS in advanced stage patients (HR and 95% confidence interval = 7.716 and 1.664–4.342, respectively). Conclusion High SUVmax is related to poor OS in patients with surgically resected early stage (stage I and II) NSCLC, but it is not an independent prognostic factor. TLG is a prognostic measurement and it is independent predictor factor of survival for advanced stage NSCLC.