Open AccessSerum zinc concentration in cystic fibrosis patients with CFTR I 1234 V mutation associated with pancreatic sufficiency
Author(s) -
AbdulWahab Atqah,
Abushahin Ahmed,
Allangawi Mona,
Chandra Prem,
Abdel Rahman Mohamed Osman,
Soliman Ashraf
Publication year - 2017
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12335
Subject(s) - cystic fibrosis , medicine , gastroenterology , zinc deficiency (plant disorder) , body mass index , albumin , pseudomonas aeruginosa , cystic fibrosis transmembrane conductance regulator , endocrinology , pathology , genetics , biology , bacteria , micronutrient
Objective To determine serum zinc (Zn) level among cystic fibrosis (CF) patients with homozygous CFTR I1234V mutation associated with pancreatic sufficiency (PS). Methods A cross‐sectional study was conducted including both pediatric and adult CF patients. Data on age, weight, height, body mass index (BMI), BMI Z ‐score, FEV1, and chronic Pseudomonas aeruginosa infection were collected. Serum Zn, albumin, and total proteins were measured and analyzed. Results Forty‐five CF patients with homozygous CFTR I1234V mutation belonging to a large Arab kindred tribe and eight CF patients with other mutations associated with pancreatic insufficiency (PI). Patient's age ranged from 2 to 49 years with a mean age of 15.1 ± 9.1 years and mean plasma Zn of 0.78 ± 0.15 mcg/mL. Seven (13.2%) patients with CFTR I1234V and PS had low Zn levels (<0.6 mcg/mL). Mean age among Zn deficient group was significantly older. The mean FEV1 in the deficient group was found to be insignificant low. Persistent P. aeruginosa colonization was more prevalent in Zn deficient group. BMI Z ‐scosre of CF patients were positively correlated with Zn levels. Forty‐five healthy subjects belonging to the same Arab tribe were selected in order to assess their Zn levels and their mean plasma Zn of 0.84 ± 0.11 mcg/mL (range 0.65–1.1 mcg/mL) with mean age 20.4 ± 10.1 years (range 6–40 years). Conclusion These findings suggest that Zn deficiency can occur in CF patients with PS. The association of Zn levels and the frequency of P . aeruginosa isolated in CF patients need further investigation.