Open AccessAsthma phenotypes in Turkey: a multicenter cross‐sectional study in adult asthmatics; PHENOTURK study
Author(s) -
Yildiz Fusun,
Mungan Dilsad,
Gemicioglu Bilun,
Yorgancioglu Arzu,
Dursun Berna,
Oner Erkekol Ferda,
Ogus Candan,
Turktas Haluk,
Bogatekin Gunhan,
Topcu Fusun,
Deveci Figen,
Bayram Hasan,
Tor Meltem,
Kalyoncu A. Fuat
Publication year - 2017
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12326
Subject(s) - medicine , overweight , asthma , nonallergic rhinitis , obesity , sinusitis , disease , pediatrics , immunology
Abstract Background and Aims To evaluate asthma phenotypes in patients with asthma from different regions of Turkey. Methods A total of 1400 adult asthmatic patients (mean (SD) age: 44.0 (13.9) years, 75% females) from 14 centers across Turkey were included in this study and a standard questionnaire was applied between the time period of February 2011–January 2012. Results The disease onset ≥ 40 years of age was higher percentage in obese vs. normal/overweight patients and nonallergic vs. allergic patients ( P < 0.01). The percentage of patients who had FEV1 values over 80% was higher in allergic than nonallergic and normal/overweight than obese patients ( P < 0.01). Uncontrolled asthmatics have more severe disease ( P < 0.01). There were more frequent hospital admissions in nonallergic and uncontrolled asthmatics ( P < 0.01). Chronic rhino‐sinusitis was the leading comorbid disorder in normal/overweight and allergic asthma, while gastroesophageal reflux disorder was more frequent in nonallergic and uncontrolled asthma ( P < 0.01). Asthma control rate was the highest (39.0%) in patients from Marmara region among all geographical regions ( P < 0.05). Conclusion In conclusion, our findings revealed existence of clinical/trigger related phenotypes based on BMI, allergic status, control level and geographical region with more frequent respiratory dysfunction and/or adverse health outcomes in uncontrolled, obese and nonallergic phenotypes.