Open AccessEndothelial dysfunction in patients with pulmonary thromboembolism: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio
Author(s) -
Kurtipek Ercan,
Büyükterzi Zafer,
Büyükterzi Meral,
Alpaydın Mehmet Sertaç,
Erdem Said Sami
Publication year - 2017
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12308
Subject(s) - medicine , endothelial dysfunction , brachial artery , lymphocyte , neutrophil to lymphocyte ratio , platelet , endothelial activation , gastroenterology , platelet activation , cardiology , pathophysiology , endothelium , immunology , blood pressure
Background and Aims Pulmonary thromboembolism ( PTE ) is a common cardiovascular emergency. Activated leukocytes may produce free oxygen radicals and endothelial damage, and, thereby, increased inflammation and thrombogenesis. In this study, we aimed to investigate endothelial dysfunction in patients with PTE . Methods Between M ay 2012 and J uly 2013, a total of 71 patients with acute PTE (32 males, 39 females; mean age: 64.94 ± 15.27 years; range: 33 to 87 years) who were admitted to the E mergency and T horacic D iseases D epartments and 56 healthy controls (44 males, 12 females; mean age: 62.52 ± 9.80 years; range: 46 to 79 years) were included. Brachial artery flow‐mediated dilation ( BFMD ) was performed. Neutrophil to lymphocyte ratio ( NLR ) and platelet to lymphocyte ratio ( PLR ) were calculated. Results Significantly higher BFMD values were observed in patients with PTE ( P < 0.05). Patients with PTE also had significantly higher NLR and PLR values, compared with the healthy control group ( P < 0.05). Conclusion The results of our study suggest that using non‐invasive method such as ultrasonography combined with NLR and PLR in endothelial dysfunction diagnosis in PTE patients are both effective and inexpensive. We believe in PTE patients endothelial dysfunction may play a role in the development of probable cardiovascular events in future.