Open AccessAssociation between genetic polymorphisms in XPD and XRCC1 genes and risks of non‐small cell lung cancer in E ast C hinese H an population
Author(s) -
Du Yong,
He Yanchao,
Mei Zhoufang,
Qian Ling,
Shi Jindong,
Jie Zhijun
Publication year - 2016
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12218
Subject(s) - xrcc1 , lung cancer , medicine , oncology , population , snp , adenocarcinoma , cancer research , genetics , cancer , biology , genotype , gene , single nucleotide polymorphism , environmental health
Background and Aims Lung cancer is a multifactorial disease. Xeroderma pigmentosum group D ( XPD ) and X ‐ray repair cross‐complementing 1 ( XRCC1 ) genes are 2 important susceptibility genes related to lung cancer. In this study, we explored the correlation between genetic polymorphisms in XPD and XRCC1 and the risk of non‐small cell lung cancer ( NSCLC ) in the E ast C hinese H an population. We also investigated risk factors associated with non‐small cell lung cancer in this population. Methods We conducted a case control study in 120 NSCLC patients and 120 healthy controls. The NSCLC patients were further divided into three subgroups, squamous carcinoma, adenocarcinoma and other type of cancer, according to tumor histology. No patients had undergone any treatment. Polymerase chain reaction and restriction fragment length polymorphism technologies were applied to detect the distribution of XPD‐751 , XRCC1‐194 and XRCC1‐399 genes in all patients. Results The results showed significant gene frequency differences for all three genes between patients with NSCLC and control patients. Significantly different frequencies of XPD ‐751‐ G ln, XRCC ‐194‐ T rp and XRCC 1‐399‐Gln mutant alleles were observed between the two groups. XPD ‐751 SNP and XRCC 1‐194 SNP frequencies varied among the three lung cancer groups, while the frequency of XRCC 1‐399 SNP did not differ significantly. Conclusions The results suggested that genetic polymorphisms in XPD‐751 , XRCC1‐194 and XRCC1‐399 were related to the risk of NSCLC , among which XPD ‐751 SNP was responsible for adenocarcinoma, while XRCC 1‐194 SNP was closely linked to squamous carcinoma. Smoking and XRCC 1‐194 SNP were risk factors of NSCLC .