Open AccessResponsiveness to methacholine, but not leukotriene D 4 , correlates with fractional exhaled nitric oxide in asthma
Author(s) -
Guan Weijie,
Shi Xu,
Jiang Caiyu,
Xie Yanqing,
Zhu Zheng,
Gao Yi,
Zheng Jinping
Publication year - 2016
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12199
Subject(s) - medicine , exhaled nitric oxide , asthma , spirometry , methacholine , inhalation , airway , anesthesia , gastroenterology , respiratory disease , lung
Background and Aims Correlation between fractional exhaled nitric oxide ( FeNO ) and responsiveness to inhaled leukotriene D 4 ( LTD 4 ) and methacholine ( MCh ) might be different. This study aims to determine the correlation between FeNO and airway responsiveness to LTD 4 and MCh , and to compare the airway responsiveness to inhaled LTD 4 and MCh and FeNO in non‐smokers, patients without rhinitis and non‐smokers without rhinitis. Methods In this cross‐over study, asthmatic patients and healthy subjects underwent LTD 4 and MCh inhalation challenge at a 2‐ to 14‐day interval. The FeNO was measured by using NIOX MINO , a portable instrument, at the initial visit, before spirometry and inhalation challenge tests. Subgroup analyses were performed in asthmatic patients based on the categorisation of never‐smoker group, non‐rhinitis group and never‐smoker without rhinitis group. Results Of 62 asthmatic patients enrolled, 43 did not have self‐reported rhinitis (asthmatic patients without rhinitis), 56 were never‐smokers (asthmatic non‐smokers), giving rise to 37 non‐smokers who did not have rhinitis (asthmatic non‐smokers without rhinitis). Twenty‐one healthy subjects were enrolled. Overall, L og 10 FeNO correlated with L og 10 PD 20 FEV 1 ‐ MCh but not L og 10 PD 20 FEV 1 ‐ LTD 4 or L og 10 ( LTD 4 / MCh potency ratio). Reduced FeNO was associated with significantly higher L og 10 PD 20 FEV 1 ‐ MCh but not L og 10 PD 20 FEV 1 ‐ LTD 4 , except for non‐smokers. Compared with all asthmatic patients, asthmatic non‐smokers without rhinitis were characterised by markedly reduced levels of L og 10 PD 20 FEV 1 ‐ MCh but not L og 10 PD 20 FEV 1 ‐ LTD 4 . The difference in all parameters did not reach statistical significance among asthmatic patients without rhinitis, asthmatic non‐smokers and asthmatic non‐smokers without rhinitis. Conclusion FeNO correlates with airway responsiveness to inhaled MCh but not LTD 4 , in asthmatic patients, particularly in asthmatic non‐smokers without rhinitis.