Open AccessPredictive value of serum Hs‐CRP levels for outcomes of pulmonary embolism
Author(s) -
Araz Omer,
Yilmazel Ucar Elif,
Yalcin Aslıhan,
Kelercioglu Nazli,
Meral Mehmet,
Gorguner Ali Metin,
Akgun Metin
Publication year - 2016
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12196
Subject(s) - medicine , pulmonary embolism , c reactive protein , gastroenterology , observational study , inflammation
Background The diagnostic utility of novel biomarkers in patients with suspected pulmonary embolism ( PE ) is still under investigation. While many studies emphasize that high serum levels of high‐sensitivity C ‐reactive protein ( Hs‐CRP ) has a moderate relation with PE , few studies show that Hs‐CRP can be used to predict the outcome of the treatment. Aims In this study, we aimed to determine whether there is a relationship between serum levels of H s‐CRP and reperfusion of pulmonary tissue. As a secondary objective, the correlation between H s‐ CRP and subgroups of PE was investigated. Methods A total of 85 patients with PE , 38 male (44.7%) and 47 female (55.3%) with an average age of 65.5 ± 13.4, were included in this prospective observational study. Samples of blood were collected before and 48 h after the inception of fibrinolytic therapy. Result The correlation of changes in serum Hs‐CRP levels with reperfusion duration was statistically significant (r = 0.548, P = 0.01). Second, we found that some subgroups of PE (massive PE : r = 0.719, P = 0.001, and minor PE : r = 0.529, P = 0.001) had a relation with changes in serum Hs‐CRP levels, whereas some had none (submassive PE : r = 0.136, P = 0.215). Conclusion Changes in serum Hs‐CRP levels can be a potential predictor of the outcomes for patients with PE . Additionally, this value of change can notify the presence of some subgroups of PE (massive and minor PE ).