Open AccessPulmonary embolism is associated with current morphine treatment in patients with deep vein thrombosis
Author(s) -
Lee Cynthia WeiSheng,
Muo ChihHsin,
Liang JiAn,
Sung FungChang,
Kao ChiaHung,
Yeh JunJun
Publication year - 2015
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12130
Subject(s) - medicine , pulmonary embolism , deep vein , odds ratio , confidence interval , thrombosis , morphine , retrospective cohort study , population , cohort , logistic regression , anesthesia , surgery , environmental health
Objectives This study investigates the relationship between current morphine use and the risk of pulmonary embolism ( PE ) development in deep vein thrombosis ( DVT ) patients. Methods We conducted a population‐based nested case‐control retrospective analysis using the L ongitudinal H ealth I nsurance D atabase 2000 of T aiwan. A DVT cohort of 3668 patients with no history of PE from 1998 to 2010 and the other cohort of 174 patients who subsequently developed PE were evaluated. Morphine use was designated as ‘current’ if the prescription duration covered the index date or ended within 30 days before the index date. Logistic regression was used to estimate the odds ratios and 95% confidence intervals ( CI ), and the multivariable model was applied to control for age. Results Compared with non‐morphine users, DVT patients who received morphine within 30 days of the index date had a 4.54‐fold (95% CI = 2.30–8.97) chance of developing PE . The risk of PE development increased with an increase in cumulative dosage and in the average dosage of morphine. Conclusion The incidence of PE in DVT patients in Taiwan is associated with current morphine treatment (≤30 days) and is dependent on dosage.