Open AccessClinical efficacy of peramivir in adult patients with seasonal influenza during the winter of 2012 in J apan
Author(s) -
Yoshino Yusuke,
Seo Kazunori,
Koga Ichiro,
Kitazawa Takatoshi,
Ota Yasuo
Publication year - 2015
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12129
Subject(s) - medicine , oseltamivir , neuraminidase inhibitor , clinical efficacy , incidence (geometry) , neuraminidase , virology , virus , covid-19 , physics , disease , infectious disease (medical specialty) , optics
Background Peramivir is an intravenously administered neuraminidase inhibitor for influenza. The clinical efficacy of peramivir remains unclear because it is used in a limited number of countries. We compared the clinical efficacy of peramivir with that of oseltamivir in influenza patients during the 2012–2013 season. Methods Thirty‐two influenza patients who were hospitalized at T eikyo U niversity H ospital, a teaching hospital in T okyo, J apan, from O ctober 2012 to M arch 2013 were enrolled. Among them, 23 and 9 were treated with peramivir and oseltamivir, respectively. The end points of this study were the time to defervescence and survival rate. Results There were no significant differences in the clinical backgrounds of the two groups. However, patients treated with peramivir tended to have a higher incidence of consciousness disturbance [34.8% (8/23) vs 0.00% (0/9), P = 0.064]. There were no significant differences between the peramivir and oseltamivir groups with respect to the time to defervescence (30.9 ± 18.7 h vs 34.7 ± 18.6 h) or survival rate [95.7% (22/23) vs 100% (9/9), respectively]. Conclusions The clinical efficacy of peramivir is non‐inferior to that of oseltamivir, although peramivir tended to be used in patients with serious complications. Intravenous administration of peramivir may be useful for patients with serious complications, such as consciousness disturbances.