Open AccessRelationship between parenchymal involvement and obstructive sleep apnea in subjects with sarcoidosis
Author(s) -
Bingol Zuleyha,
Pihtili Aylin,
Gulbaran Ziya,
Kiyan Esen
Publication year - 2015
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12098
Subject(s) - medicine , obstructive sleep apnea , spirometry , polysomnography , sarcoidosis , vital capacity , apnea–hypopnea index , body mass index , cardiology , lung volumes , sleep apnea , lung , apnea , diffusing capacity , asthma , lung function
Increased obstructive sleep apnea ( OSA ) incidence has been reported in sarcoidosis. However, no research has been conducted to determine the relation between OSA and pulmonary parenchymal involvement in sarcoidosis. Objectives We investigated OSA frequency and association between pulmonary parenchymal involvement and OSA in sarcoidosis. Additionally, relationship between lung functions and polysomnography data was assessed. Methods The study enrolled sarcoidosis subjects with or without pulmonary parenchymal involvement. Spirometry, diffusion capacity, 6‐min walking test, arterial blood gases, chest X ‐ray, E pworth sleepiness scale ( ESS ) and polysomnography were performed. Subjects with body mass index ( BMI ) ≥30 or significant upper airway pathologies that might cause OSA were excluded. Results A total of 29 sarcoidosis subjects (15 with, 14 without parenchymal involvement) with mean age 43.8 ± 9.4 years were analyzed. Twenty‐seven of them were female. BMI was 26.8 ± 4.2 kg/m 2 . Mean forced expiratory volume 1 s ( FEV 1 ) was 97.89% ± 20.21%, and forced vital capacity ( FVC ) was 102.86 ± 18.14%. ESS score was 4 ± 1.6. OSA was identified in 51.7% ( n = 15) of subjects. Apnea‐hypopnea index ( AHI ) was 16.16 ± 19/h and oxygen desaturation index ( ODI ) was 22.3 ± 25.99 among subjects with OSA . Sleep apnea related with rapid eye movement was present in 40% of OSA subjects. AHI and ODI were higher among sarcoidosis subjects with parenchymal involvement ( P = 0.019, P = 0.026). OSA frequency was higher in the group with parenchymal involvement, but the difference was not statistically significant ( n = 10/15, %66 vs n = 5/14, %35). FEV 1 and FVC were not related with AHI and ODI . Conclusion We found a high rate of OSA in sarcoidosis. There was a trend of high OSA frequency in sarcoidosis subjects with parenchymal involvement.