Open AccessHypovitaminosis D in patients with cystic fibrosis: a cross‐section study in S outh B razil
Author(s) -
Marcondes Natália Aydos,
Raimundo Fabiana Viegas,
Vanacor Roberta,
Corte Bruno Pellini,
Ascoli Aline Maria,
Azambuja Aline Zimmermann,
Scopel Luciano,
Santos Patrícia Vargas,
Dalcin Paulo de Tarso Roth,
Rotta Liane Nanci,
Furlanetto Tania Weber,
Faulhaber Gustavo Adolpho Moreira
Publication year - 2014
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12097
Subject(s) - medicine , cystic fibrosis , vitamin d and neurology , gastroenterology , spirometry , vitamin d deficiency , hypovitaminosis , malabsorption , parathyroid hormone , vitamin , endocrinology , calcium , asthma
Cystic fibrosis ( CF ) patients have a susceptibility to vitamin D deficiency because of nutrient malabsorption. Objectives To evaluate the prevalence of hypovitaminosis D in CF patients and the factors associated with serum 25‐hydroxyvitamin D levels. Methods We evaluated the prevalence of vitamin D deficiency defined as 25‐hydroxyvitamin D <30 ng/m L , as suggested recently by the C ystic F ibrosis F oundation, and factors associated with its serum levels. Patients with confirmed CF were included. Nutritional status and hospital admissions were evaluated. Serum C ‐reactive protein, calcium, phosphate, magnesium, albumin, 25‐hydroxyvitamin D and parathyroid hormone levels were measured. Lung function was evaluated by spirometry, and clinical and chest radiographic scores were assessed. Statistical significance level was set at P < 0.05. Results Fifty‐nine patients were included. Prevalence of hypovitaminosis D was 61%. Patients with pancreatic insufficiency had a trend to have higher vitamin D levels. Sixteen patients had severe lung disease with percentage of forced expiratory volume in 1 s predicted below 40%. After multivariate analysis, body mass index and hospitalization in the last month remained significantly associated with serum vitamin D levels. Conclusions Vitamin D insufficiency is still a problem in CF patients, even in those receiving supplementation.