Open AccessSustained improvement of gas exchange and lung mechanics by vaporized perfluorocarbon inhalation in piglet acute lung injury model
Author(s) -
Wang Xiaoguang,
Zhang Jianpeng,
Li Xiaoling,
Liu Youning,
Yang Haibo,
Zhao Xiaowei,
Xie Lixin,
Yin Lihua
Publication year - 2014
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12053
Subject(s) - medicine , ards , lung , inhalation , pulmonary compliance , anesthesia , oxygenation , ventilation (architecture) , mechanical engineering , engineering
New methods for perfluorocarbon ( PFC ) application have been proposed which include aerosolization and vaporization. However, the experimental documentation of efficacy of vaporization of PFC in the treatment of acute respiratory distress syndrome ( ARDS ) is still lacking. Objectives This study aims to examine the effects of vaporized PFC on gas exchange and lung mechanics in a piglet model with ARDS . Methods Lung injury was induced in 16 piglets by infusing detergent through tracheal intubation. Eight piglets were treated with vaporized PFC for 2 h followed by 6 h of volume‐controlled ventilation. Another eight piglets receiving 8 h volume‐controlled ventilation were used as controls. Blood gases, lung mechanical and hemodynamic parameters were measured. Results Vaporized PFC treatment significantly increased oxygenation index ( P / F ratio) and static lung compliance ( C st) 2 h after therapy compared with the control group ( P < 0.05). The P / F ratio reached a peak 5.5 h after the therapy and remained at an increased level for at least 6 h compared with the control group ( P < 0.001). Additionally, 6 h post treatment, peak inspiratory pressure was significantly reduced in PFC group when compared with the control group ( P < 0.05), and C st was significantly higher in the PFC group than in the control group ( P = 0.001). Conclusions Inhalation of vaporized PFC results in sustained improvement of pulmonary gas exchange and lung mechanics in a detergent‐induced animal model of lung injury. Therefore, the non‐invasive vaporization application technique would be a reasonable alternative to administer perfluorocarbons in severe lung injury.