Open AccessHistogenesis of pulmonary sclerosing hemangioma and significance of P 63 expression
Author(s) -
Zhang Jiayu,
Wang Jian
Publication year - 2014
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12048
Subject(s) - histogenesis , medicine , expression (computer science) , hemangioma , pathology , immunohistochemistry , computer science , programming language
Abstrsct Objective To investigation of the histogenesis and the significance of expression of P 63 in pulmonary sclerosing hemangioma ( SH ). Methods Eighteen cases of SH were retrospectively studied, and P 63, surfactant protein B ( SPB ), thyroid transcription factor‐1 ( TTF ‐1), epithelial membrane antigen ( EMA ), cytokeratin ( CK pan), vimentin, SMA , chromagranin ( CgA ), S yn and CD 34 were immunohistochemically labelled with EnV ision method. Results There are mainly four types of structures in SH tissue: solid, papillary, angiomatous (haemorrhagic), and sclerotic pattern. The tumour cells are composed mainly of two types of cells: cuboidal tumour cells and polygonal cells. The immunohistochemistry showed that cuboidal tumour cells expressed P 63 (+++) in 16 cases of SH (16/18 cases). Polygonal cells and cuboidal cells of all cases express both TTF ‐1 and EMA at the same time (18/18 cases); cuboidal tumour cells express SPB (18/18 cases); polygonal tumour cells express vimentin (18/18 cases). In one case, a polygonal tumour cell weakly expressed Chromogranin ( CgA ) and S yn. Conclusion The P 63 positive cuboidal tumour cells may be pluripotent original respiratory epithelial cells, with multidirectional differentiation capacity. Immunohistochemically labelling of P 63 may have important value for SH diagnosis.