Open AccessPolymorphisms of the ADAM 33 gene and chronic obstructive pulmonary disease risk: a meta‐analysis
Author(s) -
Aierken Haidiya,
Wang Jing,
Wushouer Qimanguli,
Shayhidin Elnur,
Hu Xing,
Syed Ikramullah,
Wufuer Dilinuer
Publication year - 2014
Publication title -
the clinical respiratory journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.789
H-Index - 33
eISSN - 1752-699X
pISSN - 1752-6981
DOI - 10.1111/crj.12046
Subject(s) - medicine , meta analysis , odds ratio , copd , confidence interval , subgroup analysis , pulmonary disease , case control study , bioinformatics , biology
Background The T 1 (rs2280091), S 1 (rs3918396) and S 2 (rs528557) polymorphisms in a disintegrin and metalloprotease ( ADAM 33) gene has been implicated in susceptibility of chronic obstructive pulmonary disease ( COPD ). But, a number of studies have reported inconclusive results. The aim of this study is to investigate the relationship between T 1 (rs2280091), S 1 (rs3918396) and S 2 (rs528557) polymorphisms in ADAM 33 gene and COPD risk by meta‐analysis. Methods We searched P ubmed database, E mbase database, C hinese N ational K nowledge I nfrastructure database and W anfang database, covering all studies till S eptember 5, 2012. Statistical analysis was performed using software METAGEN ( STATA 12.0) and R evman5.0. Results A total of 2139 COPD cases and 3765 controls in 10 case‐control studies were included in this study. The results showed that S 2 (rs528557) and T 1 (rs2280091) polymorphisms did not result in an increased or a decreased risk of COPD . The analysis described in this report demonstrated that S 1 (rs3918396) polymorphism ( GG + AG vs AA ) was significantly associated with the total and A sian. Odds ratio ( OR ) total = 1.27 [95% confidence interval ( CI ) 1.03–1.56, P = 0.03], OR Asian = 1.44 (95% CI 1.13–1.83, P = 0.003) but not with C aucasians. Conclusions This meta‐analysis suggested that S 1 (rs3918396) polymorphism of ADAM 33 is associated with increased risk of COPD in A sian ( C hina) but not in C aucasians. Future studies are needed to validate our conclusions.