Open AccessEmerging role and therapeutic implication of mTOR signalling in intervertebral disc degeneration
Author(s) -
Chen HaiWei,
Zhou JianWei,
Zhang GuangZhi,
Luo ZhangBin,
Li Lei,
Kang XueWen
Publication year - 2023
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.13338
Subject(s) - autophagy , pi3k/akt/mtor pathway , microbiology and biotechnology , oxidative stress , degeneration (medical) , intervertebral disc , extracellular matrix , biology , kinase , signal transduction , senescence , regeneration (biology) , medicine , apoptosis , cancer research , pathology , anatomy , genetics , endocrinology
Intervertebral disc degeneration (IDD), an important cause of chronic low back pain (LBP), is considered the pathological basis for various spinal degenerative diseases. A series of factors, including inflammatory response, oxidative stress, autophagy, abnormal mechanical stress, nutritional deficiency, and genetics, lead to reduced extracellular matrix (ECM) synthesis by intervertebral disc (IVD) cells and accelerate IDD progression. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that plays a vital role in diverse degenerative diseases. Recent studies have shown that mTOR signalling is involved in the regulation of autophagy, oxidative stress, inflammatory responses, ECM homeostasis, cellular senescence, and apoptosis in IVD cells. Accordingly, we reviewed the mechanism of mTOR signalling in the pathogenesis of IDD to provide innovative ideas for future research and IDD treatment.