Open AccessThe role of the Wnt signalling pathway in the energy metabolism of bone remodelling
Author(s) -
Zhu Mengyuan,
Fan Zhipeng
Publication year - 2022
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.13309
Subject(s) - bone remodeling , wnt signaling pathway , microbiology and biotechnology , bone resorption , bone cell , energy metabolism , sclerostin , signal transduction , biology , chemistry , endocrinology
Objectives Bone remodelling is necessary to repair old and impaired bone caused by aging and its effects. Injury in the process of bone remodelling generally leads to the development of various bone diseases. Energy metabolism plays crucial roles in bone cell formation and function, the disorder of which will disrupt the balance between bone formation and bone resorption. Materials and Methods Here, we review the intrinsic interactions between bone remodelling and energy metabolism and the role of the Wnt signalling pathway. Results We found a close interplay between metabolic pathways and bone homeostasis, demonstrating that bone plays an important role in the regulation of energy balance. We also discovered that Wnt signalling is associated with multiple biological processes regulating energy metabolism in bone cells. Conclusions Thus, targeted regulation of Wnt signalling and the recovery of the energy metabolism function of bone cells are key means for the treatment of metabolic bone diseases.