Open AccessPhosphorylation of Yun is required for stem cell proliferation and tumorigenesis
Author(s) -
Ren Xuejing,
Zhao Hang,
Shi Lin,
Li Zhengran,
Kong Ruiyan,
Ma Rui,
Jia Lemei,
Lu Shan,
Wang JianHua,
Dong Mengqiu,
Wang Yingchun,
Li Zhouhua
Publication year - 2022
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.13230
Subject(s) - phosphorylation , stem cell , microbiology and biotechnology , cell growth , carcinogenesis , biology , cell , biochemistry , gene
Stem cells maintain adult tissue homeostasis under physiological conditions. Uncontrolled stem cell proliferation will lead to tumorigenesis. How stem cell proliferation is precisely controlled is still not fully understood. Phosphorylation of Yun is essential for ISC proliferation. Yun is essential for the proliferation of normal and transformed intestinal stem cells. Our mass spectrometry and biochemical data suggest that Yun can be phosphorylated at multiple residues in vivo. Interestingly, we show that the phosphorylation among these residues is likely interdependent. Furthermore, phosphorylation of each residue in Yun is important for its function in ISC proliferation regulation. Thus, our study unveils the important role of post‐translational modification of Yun in stem cell proliferation.